The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau–Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep
نویسندگان
چکیده
Epilepsy with continuous spike- and -waves during slow-wave sleep and Landau-Kleffner syndrome are two rare childhood epilepsy syndromes. The underlying pathophysiology remains unknown. The current opinions about epidemiologic risk factors, genetic predisposition, EEG and MEG findings, influence of anti-epileptic drugs, neuroradiology, positron emission tomopgraphy, evoked potentials, auto-immunity and subpial transection are summarized.
منابع مشابه
Sleep and epilepsy syndromes.
Sleep and epilepsy have a close relationship. About 20% of patients suffer seizures only during the night, approximately 40% only during the day and approximately 35% during the day and night. In certain epilepsy syndromes, the occurrence of seizures is strongly related to sleep or awakening. Infantile spasms appear predominately on awakening, and hypsarrhythmia is sometimes visible only in sle...
متن کاملLandau–Kleffner syndrome: A study of 29 patients
PURPOSE The aim of the study was to retrospectively analyze the electroclinical features, etiology, treatment, and prognosis of 29 patients with Landau-Kleffner syndrome (LKS) with a long-term follow-up. METHODS Inclusion criteria were a diagnosis of LKS with: (1) acquired aphasia or verbal auditory aphasia; (2) with or without focal seizures, secondarily generalized tonic-clonic seizures, ab...
متن کاملEpileptic encephalopathy of late childhood: Landau-Kleffner syndrome and the syndrome of continuous spikes and waves during slow-wave sleep.
Landau-Kleffner syndrome (LKS) and the syndrome of continuous spikes and waves during slow wave sleep (CSWS) are two points on the spectrum of functional childhood epileptic encephalopathies. They are characterized by a severe paroxysmal EEG disturbance that may permanently alter the critical synaptogenesis by strengthening synaptic contacts that should have been naturally "pruned." The much mo...
متن کاملOutcome at adulthood of the continuous spike-waves during slow sleep and Landau-Kleffner syndromes.
PURPOSE The aim of this study was to determine the clinical, social, and/or professional and cognitive outcomes in adulthood of the continuous spike-waves during slow sleep (CSWS) and Landau-Kleffner syndromes, which are two rare epileptic syndromes occurring in children. METHODS We enrolled seven young adults, five who had a CSWS syndrome, and two, a Landau-Kleffner syndrome in childhood. We...
متن کاملThe relationship between sleep and epilepsy.
Seizures occur extensively during sleep or on awakening in a substantial proportion of patients with epilepsy. Interictal epileptiform discharges are also influenced by sleep and sleep deprivation. Continuous spike-waves in slow-wave sleep are the hallmark of Landau-Kleffner syndrome and ESES (Electrical Status in Slow Sleep). Sleep deprivation is known to influence not only the occurrence but ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Seizure
دوره 15 شماره
صفحات -
تاریخ انتشار 2006